Depends on where you are really, and what you need to do besides just spike damage. This is one I used for a good bit though:
Shadow Strike, Vampiric Gaze, Dark Pact, Awaken the Blood, Well of Power, +skills useful for where you are.
Basically you use shadow strike if they have >50% health, then alternate dark pact and vampiric gaze to recover your sacrificed health. Usually you will be able to do two dark pacts and then a gaze, and not end up with too much health lost from it, especially if you did Awaken and had 18 blood magic. After one enemy goes down, stand in the well of power to keep your energy and health up, the +2 energy regen will keep you casting continuously.
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